A pentapeptide studied as a selective ghrelin-receptor agonist.
Ipamorelin is a synthetic pentapeptide, a chain of five amino acids, studied in growth-hormone axis research. It is often grouped with CJC-1295, but the two work through different receptors.
Ipamorelin is a growth hormone secretagogue. It acts as an agonist at the ghrelin receptor (GHS-R1a) on the pituitary. Compared with earlier ghrelin-receptor compounds, it was characterised in the literature as more selective, meaning it was examined for GH release with less effect on other pituitary hormones such as cortisol and prolactin in the models studied.
Researchers study how ghrelin-receptor agonists produce short, pulse-like signals, which differs from the sustained signalling studied with long-acting GHRH analogs.
A major part of the Ipamorelin literature compares its selectivity against other secretagogues.
CJC-1295 is a GHRH analog; Ipamorelin is a ghrelin-receptor agonist. Different receptors, which is why they are studied as separate tools rather than interchangeable ones. Read the GHRH vs ghrelin explainer →
All of the above is research context from laboratory models. Ipamorelin is supplied for research use only and is not a treatment.
Insist on a batch-specific COA with HPLC purity and mass-spec identity. Here is how to read one.
View Ipamorelin research compound →